Hybrid small-molecule natural semiconductor / quantum dot mix movies are enticing for prime effectivity low-cost photo voltaic vitality harvesting gadgets. Understanding and controlling the self-assembly of the natural semiconductor and quantum dots is essential in optimising machine efficiency, not solely at a lab-scale however for large-scale high-throughput printing and coating strategies. Right here, in situ grazing incidence X-ray scattering (GIXS) is employed with the intention to acquire direct insights into how small-molecule natural semiconductor / quantum dot blends self-assemble throughout blade coating. Outcomes present that for 2 totally different archetypal natural small molecule:quantum dot blends, small-molecule crystallisation could both happen spontaneously or be mediated by the formation of quantum dot aggregates. No matter the preliminary crystallisation route, the small-molecule crystallisation acts to exclude the quantum dot impurities from the rising crystalline matrix section. These outcomes present essential basic understanding of construction formation of small natural molecule:quantum dot movies ready by way of answer processing routes, appropriate with massive scale deposition manufacturing.