New methodology allows research of nano-sized particles

nano particles
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Researchers at Karolinska Institutet have created a brand new methodology of learning the smallest bioparticles within the physique. The research, which is revealed in Nature Biotechnology, has appreciable scientific potential, akin to within the improvement of more practical vaccines.

Circulating across the physique are nanoparticles that have an effect on it in a method or one other. For instance, there are lipoproteins that keep , that trigger many ailments and which can be used to hold medication, like current lipid nanoparticle-based mRNA vaccines.

Nevertheless, such particles are too small to be studied simply. To allow this, the researchers on this research have developed a brand new methodology that they name single-particle profiling (SPP).

“We’re presenting a brand new methodology that provides unprecedented details about nano-sized particles,” says the research’s final writer assistant professor Erdinc Sezgin at SciLifeLab and the Division of Girls’s and Kids’s Well being, Karolinska Institutet.

The tactic makes it potential to measure the content material and properties of hundreds of particles between 5 and 200 nanometers in measurement.

“Our methodology can be utilized to review bioparticles in well being and illness.” says Dr. Sezgin. “Furthermore, it is going to even be a useful instrument in creating higher and more practical nanocarriers.”

One of many researchers’ targets was to create a easy, cheap methodology accessible to all researchers.

“We established a way based mostly on commercially obtainable microscopes and made our data-analysis instrument and all our knowledge freely obtainable,” says Dr. Sezgin.

Extra data:
Taras Sych et al, Excessive-throughput measurement of the content material and properties of nano-sized bioparticles with single-particle profiler, Nature Biotechnology (2023). DOI: 10.1038/s41587-023-01825-5.

New methodology allows research of nano-sized particles (2023, June 12)
retrieved 12 June 2023

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